Stephen P. Diggle
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Stephen P. Diggle | |
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| Born | Stephen P. Diggle |
| Nationality | British, American |
| Other names | Steve Diggle |
| Known for | Research on microbial interactions, bacterial social behavior, chronic infections, and antimicrobial resistance |
| Scientific career | |
| Fields | Microbiology |
| Website | digglelab |
Stephen P. Diggle (Steve Diggle) is a British/American microbiologist who is currently a Professor in the https://biosciences.gatech.edu/ School of Biological Sciences at the Georgia Institute of Technology (Georgia Tech), where he is also the Director of the https://sites.gatech.edu/cmdi/ Center for Microbial Dynamics and Infection. His research focuses on microbial interactions, social behaviors, and the role of these dynamics in chronic infection and antimicrobial resistance. His lab website can be found https://www.thedigglelab.com/ here.
Academic Career
Diggle graduated from the University of Salford with a B.Sc. in Biological Sciences in 1997. He went on to complete his Ph.D. in molecular microbiology at the University of Nottingham in 2001, where he studied quorum sensing in the opportunistic pathogen Pseudomonas aeruginosa.Following his doctoral work, he held a Postdoctoral Fellowship at the University of Nottingham. From 2006 to 2014, he held a Royal Society University Fellowship. He was promoted to Associate Professor in 2013 before moving to the United States. In 2017, Diggle joined the School of Biological Sciences at the Georgia Institute of Technology as an Associate Professor and was promoted to Full Professor in 2022.
Research Interests
Professor Diggle's research primarily investigates the opportunistic pathogen Pseudomonas aeruginosa, which is a major cause of chronic, debilitating lung infections in patients with cystic fibrosis (CF) and is known for its high levels of antibiotic resistance.
His lab's core research areas include:
- Novel Therapeutic Strategies: Research into developing new treatments, including exploring the potential of R-pyocins (bacteriocins) as targeted antimicrobials against P. aeruginosa[1][2] and his involvement in the AncientBiotics Consortium, which investigates the antimicrobial properties of ancient medical remedies.[3]
- Quorum Sensing and Social Cheating: He has a long-standing interest in how bacteria communicate via quorum sensing (cell-to-cell signaling)[4][5][6] and how cooperative behaviors are maintained in microbial populations, particularly concerning the ecological and evolutionary consequences of "cheats" (non-producing individuals) that exploit communal resources ("public goods") like secreted virulence factors.
- Antimicrobial Resistance (AMR) and Evolution: Investigating how P. aeruginosa evolves and adapts to treatment during chronic infections in the CF lung. This includes studying the role of genomic diversification and evolutionary trade-offs in AMR.[7][8]
Honors and Recognition
- Elected to the American Academy of Microbiology (2023)
- American Society for Microbiology Distinguished Lecturer (2021–2023)
- Cullen-Peck Scholar Award (Georgia Tech, 2020)
- Fleming Prize awarded by the Microbiology Society (2010)
- Recipient of a Royal Society University Fellowship (2006–2014)
Editorial Roles
Diggle is the Deputy Editor in Chief of the journal Microbiology and also serves as an Editor for mBio. He has previously served on the editorial boards of several other microbiology-focused journals.
Personal Life
In his spare time, Diggle plays the bass guitar and has played in a number of UK and US bands, including recording original music with a band called https://meaner.bandcamp.com/ Meaner and he currently plays in a covers band called The Variants of Concern. He also has a strong interest in the works of J.R.R. Tolkien.
References
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- ↑ Oluyombo, Olubukola; Penfold, Christopher N.; Diggle, Stephen P. (2019-01-29). "Competition in Biofilms between Cystic Fibrosis Isolates of Pseudomonas aeruginosa Is Shaped by R-Pyocins". mBio. 10 (1): e01828–18. ISSN 2150-7511. PMC 6355985. PMID 30696740.
- ↑ Harrison, Freya; Roberts, Aled E. L.; Gabrilska, Rebecca; Rumbaugh, Kendra P.; Lee, Christina; Diggle, Stephen P. (2015-08-11). "A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity". mBio. 6 (4): e01129. doi:10.1128/mBio.01129-15.
- ↑ Soto-Aceves, Martin P.; Diggle, Stephen P.; Greenberg, E. Peter (2023). "Microbial Primer: LuxR-LuxI Quorum Sensing". Microbiology (Reading, England). 169 (9): 001343. doi:10.1099/mic.0.001343.
- ↑ Azimi; Klementiev, Alexander D.; Whiteley, Marvin; Diggle, Stephen P. (2020-09-08). "Bacterial Quorum Sensing During Infection". Annual Review of Microbiology. 74: 201–219. doi:first1=Sheyda.
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- ↑ Vanderwoude, Jelly; Azimi, Sheyda; Read, Timothy D.; Diggle, Stephen P. (2024-02-14). "The role of hypermutation and collateral sensitivity in antimicrobial resistance diversity of Pseudomonas aeruginosa populations in cystic fibrosis lung infection". mBio. 15 (2): e0310923. doi:10.1128/mbio.03109-23. ISSN 2150-7511. PMC 10865868. PMID 38171021.
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External links
This article "Stephen P. Diggle" is from Wikipedia. The list of its authors can be seen in its historical. Articles taken from Draft Namespace on Wikipedia could be accessed on Wikipedia's Draft Namespace.